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Title   진행된 두경부암에 대한 EAP 복합화학요법 ( EAP Combination Chemotherapy in Patients with Advanced Head and Neck Cancer )
Publicationinfo   1991 Jan; 023(02): 380-387.
Key_word   Head and neck cancer, Chemotherapy
Full-Text  
Abstract   24 patients with advanced head and neck cancer were treated with etoposide doxarubicin and cisplatin (EAP) combination therapy between July, 1987 and April, 1990. 1) Among 16 evaluable patients, overall response rate was 68% (complete response 25% partial response rate 43%). 2) Median response duration were 7 month for responders, 4 month and 17.5 month far partial responders and complete responders respectively. 3) Median survival was 10 month for overall patients and 15 month and 5 month for responders and nonrespoders; there was statistically significant difference (p<0.01). 4) There was na significant statistical difference in the response rate sccoding to patient charicteristics. 5) Frequent non-hematologic toxicity were nausea and vomiting. Alopecia, stomatitis, fever and diarrhea were observed infrequently, leukopenia and thrombocytopenia were observed in 8%, hepatotoxicity and nephrotoxicity were observed in 8%, hepatotoxicity and nephrotoxicity were minimaL In conclusion, EAP cmbination chemotherapy in patients with advanced head neck cancer was moderately effective and well tolerable.
저 자   윤일국(Ill Kuk Yoon),김종완(Jong Wan Kim),길준영(Jun Young Kil),전의건(Eui Gun Chun),김삼용(Sam Yong Kim),유장렬(Jang Yuorl Yoo)